The Rómulo Gallegos International Novel Prize (Spanish: Premio internacional de novela Rómulo Gallegos) was established on August 6, 1964, by a presidential decree signed by Venezuelan president Raúl Leoni. It was created to honor Rómulo Gallegos, a Venezuelan writer and former president, who is best known for writing Doña Bárbara.

The goal of the prize is to "continue honoring the work of this famous novelist and to encourage creative writing by Spanish language authors."

The prize is given by the government of Venezuela through the Rómulo Gallegos Center for Latin American Studies (CELARG). The first award was presented in 1967. From 1967 to 1987, the prize was given every five years. After 1987, it became a biennial award, given every two years.

The winner receives a cash prize of €100,000, making it one of the most valuable literary prizes in the world.