The PEN/Ralph Manheim Medal for Translation, named after U.S. translator Ralph Manheim, is a literary award given every three years by PEN America (the U.S. chapter of International PEN) to a translator who has shown dedication to high-quality work throughout their career. The Medal honors a lifetime of achievements in literary translation.

It was first given in 1982 to Gregory Rabassa, who translated works by Gabriel García Márquez, Mario Vargas Llosa, and other important Latin American writers.

The medal is one of many PEN awards given by groups connected to International PEN in more than 145 locations worldwide. PEN American Center awards are considered some of the most important American literary prizes. The PEN/Ralph Manheim Medal is called one of the most important translation awards.